The role of Rosa damascena Mill. on acute hypoxia

Document Type : Original Article

Authors

1 Pharmaceutical Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran

2 Student Research Committee, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

3 Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

4 Student Research Committee and Pharmaceutical Sciences Research Center, School of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

Abstract

Background: In the Rosaceae family, Rosa damascene Mill. is an important medicinal plant. Studies reported its antioxidant, cardioprotective, and neuroprotective effects that may be related to the anti-hypoxic activity. So, we investigated the anti-hypoxic effects of R. damascenaare in this study to evaluate the possible mechanism of plant effectiveness in cardiovascular and neurological disease.
Methods: The R. damascenaare flowers were extracted with methanol by maceration method and anti-hypoxic activities were evaluated in haemic, asphyctic, and circulatory models.
Results: In asphyctic hypoxia, extract at 250 mg/kg increased the survival time to 21.53±1.21 minutes, which was significantly lower (P<0.0001) than phenytoin (29.60±1.34 minutes). In haemic hypoxia, extract effects were similar to propranolol (P>0.05) at 125, and 250 mg/kg (15.85±0.69 and 16.19±1.71 vs. 16.44±1.39 minutes, P>0.05). In circulatory hypoxia, extract significantly increased the survival time at 250 mg/kg compared to the negative control (13.64±1.51 vs. 9.79±0.56 minutes, P<0.01) but its effect was weaker than propranolol (16.44±1.39 minutes).
Conclusion: R. damascenaare show potent anti-hypoxic activity in the haemic model. Its effects were significant in higher doses in asphyctic and circulatory models.

Keywords

Natural Compounds Chemistry
Volume 2, Issue 1
October 2023
Pages 60-67

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